Invited Speaker 7th Modern Solid Phase Peptide Synthesis & Its Applications Symposium 2019

Peptide Derived Sensors for Biologically Relevant Oxoanions  (#36)

Katrina Jolliffe 1
  1. The University of Sydney, Sydney, NSW, Australia

The phosphate anion and its derivatives play fundamental roles in numerous biological and chemical processes. The ability to selectively recognize such anions in competitive solvents has potential applications across diverse fields including medicinal chemistry and diagnostics. Zinc(II)dipicolylamino complexes have been found to exhibit high selectivity towards phosphate oxoanions and positioning two of these groups on an appropriate scaffold can provide discrimination between different phosphate derivatives.1

We report here our recent work using bis[Zn(II)dipicolylamine] (Zn(II)DPA) binding sites on peptidic scaffolds for sensing a variety of phosphate derivatives, including pyrophosphate and phosphatidylserine.2 

  1. S. Lee, K. K. Y. Yuen, K. A. Jolliffe and J. Yoon, Chem. Soc. Rev., 2015, 44, 1749-1762; K. A. Jolliffe, Acc. Chem. Res., Acc. Chem. Res., 2017, 50, 2254-2263; H. T. Ngo, X. Liu and K. A. Jolliffe, Chem. Soc. Rev., 2012, 41, 4928-4965.
  2. V. E. Zwicker, B. L. Oliveira, J. H. Yeo, S. T. Fraser, G. J. L. Bernardes, E. J. New and K. A. Jolliffe, Angew. Chem. Int. Ed., 2019, DOI: 10.1002/anie.201812489.